Think of the Daintree as the wider rainforest region and Cape Tribulation as the iconic stretch where rainforest meets reef. Most visitors experience both on the same trip — boardwalks, lookouts, and a river cruise inland, then beaches and coastal walks further north.
Choose Cape Tribulation lodging if you want to wake up in the thick of it. Stay closer to Port Douglas or Mossman if you prefer easier dining and day trips without as much driving after dark.